5-(2,2,2-Trifluoroethoxy)pyridine-2-carboxylic acid → HCID 86651227, compound

HRID 1929507Notes

Reaction equation

HRID 1929507 reaction equation
[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]([OH:13])=O)=[N:9][CH:10]=1.[NH2:16][C:17]1[CH:18]=[C:19]([C:23]2([CH3:30])[NH:28][C:27](=[S:29])[CH2:26][O:25][CH2:24]2)[CH:20]=[CH:21][CH:22]=1>>[CH3:30][C:23]1([C:19]2[CH:18]=[C:17]([NH:16][C:11]([C:8]3[CH:7]=[CH:6][C:5]([O:4][CH2:3][C:2]([F:1])([F:15])[F:14])=[CH:10][N:9]=3)=[O:13])[CH:22]=[CH:21][CH:20]=2)[CH2:24][O:25][CH2:26][C:27](=[S:29])[NH:28]1

Participants

3

Reactant 2

HCID 574758545-(2,2,2-Trifluoroethoxy)pyridine-2-carboxylic acidHCID 58155249(RS)-5-(3-amino-phenyl)-5-methyl-morpholine-3-thione

Product 1

HCID 86651227HCID 86651227, compound

Procedure

In a reaction analogous to that described in example 6 (method B), the condensation of 5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (CAS 881409-53-6) with Building block F, (RS)-5-(3-amino-phenyl)-5-methyl-morpholine-3-thione, yielded the title compound as a as light yellow oil (64% of theory). Mass (calculated) C19H18F3N3O3S [425.43]; (found) [M+H]+=426.

Workup

  1. customIn a reaction analogous to

Sources & evidence

ORD record
ord-8080189314e04841a3ba485ef3925e43
Source dataset
uspto-grants-2012_05
Patent number
US08188079B2

Reaction notes

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