Lithium Hydroxide → 5-(Cyclopropylmethoxy)pyridine-2-carboxylic acid

HRID 1929512Notes

Reaction equation

HRID 1929512 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:7][N:6]=1)=[O:4].[OH-].[Li+]>>[CH:13]1([CH2:12][O:11][C:8]2[CH:9]=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=2)[CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 669314875-Cyclopropylmethoxy-pyridine-2-carboxylic acid methyl ester

Product 1

HCID 666918955-(Cyclopropylmethoxy)pyridine-2-carboxylic acid

Procedure

In a manner analogous to that described in example 48b) the hydrolysis of 5-cyclopropylmethoxy-pyridine-2-carboxylic acid methyl ester with lithium hydroxide yielded the title compound as a white solid. Mass (calculated) C10H11NO3 [193.201]; (found) [M+H]+=194.

Sources & evidence

ORD record
ord-e9aaf20e79764af59bd16af28c3287fb
Source dataset
uspto-grants-2012_05
Patent number
US08188079B2

Reaction notes

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