2-Bromobutane → HCID 66931655, compound

HRID 1929519Notes

Reaction equation

HRID 1929519 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:11][CH3:12])[C:5]([C:8]([OH:10])=[O:9])=[N:6][CH:7]=1.Cl[C:14]1C=CC(C(O)=O)=N[CH:19]=1.BrC(CC)C>>[CH:11]([C:4]1[C:5]([C:8]([OH:10])=[O:9])=[N:6][CH:7]=[C:2]([Cl:1])[CH:3]=1)([CH2:14][CH3:19])[CH3:12]

Participants

4

Reactant 3

HCID 65542-BromobutaneHCID 27628725-Chloro-2-picolinic acidHCID 66931452HCID 66931452, compound

Product 1

HCID 66931655HCID 66931655, compound

Procedure

The (RS)-3-sec-butyl-5-chloro-pyridine-2-carboxylic acid was prepared in analogy to the preparation of 5-chloro-3-ethyl-pyridine-2-carboxylic acid by treatment of 5-chloropyridine-2-carboxylic acid with 2-bromo-butane. The (RS)-3-sec-butyl-5-chloro-pyridine-2-carboxylic acid was obtained as a white solid (yield: 6% of theory). Mass (calculated) C10H12ClNO2 [213.66]; (found) [M+H]+=213, [M+2-H]+=215.

Sources & evidence

ORD record
ord-1f0987db645c4d76b6c5e318880db74f
Source dataset
uspto-grants-2012_05
Patent number
US08188079B2

Reaction notes

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