Ammonia → HCID 24205344, compound

HRID 1929545Notes

Reaction equation

C[O:2][C:3](=[O:35])[C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[CH2:9][C:10]1[C:11]2[C:16]([C:17]3[CH:18]=[C:19]4[O:26][CH2:25][O:24][C:20]4=[CH:21][C:22]=3[CH:23]=1)=[CH:15][C:14]([O:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=[CH:13][CH:12]=2.N>>[CH2:25]1[O:26][C:19]2[C:20](=[CH:21][C:22]3[CH:23]=[C:10]([CH2:9][N:5]4[CH2:6][CH2:7][CH2:8][C@H:4]4[C:3]([OH:35])=[O:2])[C:11]4[C:16]([C:17]=3[CH:18]=2)=[CH:15][C:14]([O:27][CH2:28][C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)=[CH:13][CH:12]=4)[O:24]1

Participants

Reactant 2

HCID 222Ammonia

HCID 24205685HCID 24205685, compound

Product 1

HCID 24205344HCID 24205344, compound

Procedure

General procedure e from 17 (100%); white powder; mp 147-149° C.; 1H NMR (400.13 MHz) δ 8.11 (d, J=4 Hz, 1H), 7.84 (d, J=2 Hz, 1H), 7.75 (s, 1H), 7.42 (s, 1H), 7.40 (d, J=4 Hz, 2H), 7.30 (t, J=4 Hz, 2H), 7.27 (m, 1H), 7.23 (dd, J=4 Hz, 2 Hz, 1H), 7.14 (s, 1H), 6.01 (s, 2H), 5.16 (s, 2H), 4.30 (s, 2H), 3.24 (m, 1H), 2.48 (m, 2H), 2.0 (m, 2H), 1.68 (m, 2H); MS (DCI/NH3) m/e: 456 (M+H)+. Anal. (C28H25O5N.1.0H2O) C, H, N.

Sources & evidence

ORD record: ord-849bf482238f497ab521ca2b7a7c3074
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188089B2

Reaction notes

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