Ammonia → HCID 86625134, compound

HRID 1929547Notes

Reaction equation

[CH2:1]1[O:17][C:16]2[C:3](=[CH:4][C:5]3[CH:6]=[C:7]([C:26]([N:28]4[CH2:35][CH2:34][CH2:33][C@H:29]4[C:30]([OH:32])=[O:31])=[O:27])[C:8]4[C:13]([C:14]=3[CH:15]=2)=[CH:12][C:11]([O:18]CC2C=CC=CC=2)=[CH:10][CH:9]=4)[O:2]1.N>>[CH2:1]1[O:17][C:16]2[C:3](=[CH:4][C:5]3[CH:6]=[C:7]([C:26]([N:28]4[CH2:35][CH2:34][CH2:33][C@H:29]4[C:30]([OH:32])=[O:31])=[O:27])[C:8]4[C:13]([C:14]=3[CH:15]=2)=[CH:12][C:11]([OH:18])=[CH:10][CH:9]=4)[O:2]1

Participants

Reactant 2

HCID 222Ammonia

HCID 24205681HCID 24205681, compound

Product 1

HCID 86625134HCID 86625134, compound

Procedure

General procedure g from 16 (92%); white powder; mp 230-231° C.; 1H NMR (400.13 MHz) δ 7.73 (d, J=4 Hz, 1H), 7.67 (s, 1H), 7.50 (d, J=2 Hz, 1H), 7.35 (s, 1H), 7.21 (dd, J=4 Hz, 2 Hz, 1H), 7.06 (m, 1H), 6.01 (s, 2H), 4.67 (t, J=7 Hz, 1H), 3.22 (m, 2H), 2.38 (m, 2H), 2.18 (m, 2H), 1.86 (m, 2H); MS (DCI/NH3) m/e: 380 (M+H)+.

Sources & evidence

ORD record: ord-b6661b4cfdd04d74ac6a6286ac8d1e92
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188089B2

Reaction notes

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