Ammonia → HCID 86625135, compound

HRID 1929548Notes

Reaction equation

[CH2:1]1[O:17][C:16]2[C:3](=[CH:4][C:5]3[CH:6]=[C:7]([CH2:26][N:27]4[CH2:34][CH2:33][CH2:32][C@H:28]4[C:29]([OH:31])=[O:30])[C:8]4[C:13]([C:14]=3[CH:15]=2)=[CH:12][C:11]([O:18]CC2C=CC=CC=2)=[CH:10][CH:9]=4)[O:2]1.N>>[CH2:1]1[O:17][C:16]2[C:3](=[CH:4][C:5]3[CH:6]=[C:7]([CH2:26][N:27]4[CH2:34][CH2:33][CH2:32][C@H:28]4[C:29]([OH:31])=[O:30])[C:8]4[C:13]([C:14]=3[CH:15]=2)=[CH:12][C:11]([OH:18])=[CH:10][CH:9]=4)[O:2]1

Participants

Reactant 2

HCID 222Ammonia

HCID 24205344HCID 24205344, compound

Product 1

HCID 86625135HCID 86625135, compound

Procedure

General procedure g from 18 (95%); white powder; mp 205-206° C.; 1H NMR (400.13 MHz) δ 8.07 (d, J=4 Hz, 1H), 7.82 (s, 1H), 7.80 (d, J=2 Hz, 1H), 7.42 (s, 1H), 7.21 (dd, J=4 Hz, 2 Hz, 1H), 7.10 (s, 1H), 6.04 (s, 2H), 4.09 (s, 2H), 3.16 (m, 1H), 2.38 (m, 2H), 2.23 (m, 2H), 1.95 (m, 2H); MS (DCI/NH3) m/e: 366 (M+H)+.

Sources & evidence

ORD record: ord-a0df312167b54560b9f1da44f859089d
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188089B2

Reaction notes

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