Ammonia → HCID 86625137, compound

HRID 1929551Notes

Reaction equation

[CH3:1][O:2][C:3]1[C:16]([O:17][CH3:18])=[CH:15][C:14]2[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([O:19][CH3:20])[CH:12]=3)[C:7]([CH2:21][NH:22][CH2:23][CH2:24]CCCC(O)=O)=[CH:6][C:5]=2[CH:4]=1.N>>[CH3:1][O:2][C:3]1[C:16]([O:17][CH3:18])=[CH:15][C:14]2[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([O:19][CH3:20])[CH:12]=3)[C:7]([CH2:21][NH:22][CH:23]([CH3:24])[CH2:14][CH2:5][CH2:4][CH2:3][OH:2])=[CH:6][C:5]=2[CH:4]=1

Participants

Reactant 2

HCID 222Ammonia

HCID 86625138HCID 86625138, compound

Product 1

HCID 86625137HCID 86625137, compound

Procedure

General procedure f from 35 (92%); yellow oil; 1H NMR (400.13 MHz) δ 7.88 (d, J=4 Hz, 1H), 7.76 (s, 1H), 7.71 (d, J=2 Hz, 1H), 7.44 (s, 1H), 7.13 (dd, J=4 Hz, 2 Hz, 1H), 7.05 (s, 1H), 5.99 (s, 2H), 3.94 (s, 9H), 3.80 (s, 2H), 3.73 (t, J=6 Hz, 2H), 2.75 (m, 2H), 1.50 (m, 4H), 1.28 (m, 4H); MS (DCI/NH3) m/e: 398 (M+H)+.

Sources & evidence

ORD record: ord-eed4fc81061f4709a8ea134f4c9fb5ec
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188089B2

Reaction notes

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