Ammonia → HCID 16749052, compound

HRID 1929555Notes

Reaction equation

Cl.[CH2:2]1[O:18][C:17]2[C:4](=[CH:5][C:6]3[CH:7]=[C:8]([CH2:21][NH:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][OH:29])[C:9]4[C:14]([C:15]=3[CH:16]=2)=[CH:13][C:12]([O:19][CH3:20])=[CH:11][CH:10]=4)[O:3]1.N>>[CH2:2]1[O:18][C:17]2[C:4](=[CH:5][C:6]3[CH:7]=[C:8]([CH2:21][NH:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][OH:29])[C:9]4[C:14]([C:15]=3[CH:16]=2)=[CH:13][C:12]([O:19][CH3:20])=[CH:11][CH:10]=4)[O:3]1

Participants

Reactant 2

HCID 222Ammonia

HCID 16749051HCID 16749051, compound

Product 1

HCID 16749052HCID 16749052, compound

Procedure

N-(2,3-Methylenedioxy-6-methoxy-phenanthr-9-ylmethyl)-6-aminohexanol hydrochloride (22b) White powder; mp 187-188° C.; 1H NMR (400.13 MHz) δ δ 8.14 (d, J=4 Hz, 1H), 7.82 (s, 1H), 7.76 (d, J=2 Hz, 1H), 7.50 (s, 1H), 7.18 (dd, J=4 Hz, 2 Hz, 1H), 7.13 (s, 1H), 6.08 (s, 2H), 4.67 (s, 2H), 3.98 (s, 3H), 3.60 (t, J=6 Hz, 2H), 3.44 (m, 2H), 1.66 (m, 2H), 1.59 (m, 2H), 1.40 (m, 2H), 1.33 (m, 2H); MS (DCI/NH3) m/e: 382 (M+H)+. Anal. (C23H27O4N.1.0HCl.1.5H2O) C, H, N.

Sources & evidence

ORD record: ord-071ef1fb86ff416b81bd8ae4d48a801b
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188089B2

Reaction notes

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