(6-Fluoro-4-hydroxy-naphthalen-2-yl)-acetic acid methyl ester → 7-Fluoro-3-methoxycarbonylmethyl-naphthalene-1-carboxylic acid

HRID 1929571Notes

Reaction equation

HRID 1929571 reaction equation
COC(=O)CC1C=C(O)C2C(=CC=C(F)C=2)C=1.[F:18][C:19]1[CH:28]=[C:27]2[C:22]([CH:23]=[C:24]([CH2:33][C:34]([O:36][CH3:37])=[O:35])[C:25](C)=[C:26]2[C:29]([OH:31])=[O:30])=[CH:21][CH:20]=1>>[F:18][C:19]1[CH:28]=[C:27]2[C:22]([CH:23]=[C:24]([CH2:33][C:34]([O:36][CH3:37])=[O:35])[CH:25]=[C:26]2[C:29]([OH:31])=[O:30])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 20335012(6-Fluoro-4-hydroxy-naphthalen-2-yl)-acetic acid methyl esterHCID 593267347-Fluoro-3-methoxycarbonylmethyl-2-methyl-naphthalene-1-carboxylic acid

Product 1

HCID 593267307-Fluoro-3-methoxycarbonylmethyl-naphthalene-1-carboxylic acid

Procedure

Starting with (6-fluoro-4-hydroxy-naphthalen-2-yl)-acetic acid methyl ester, using the method analogous to the one described for 7-fluoro-3-methoxycarbonylmethyl-2-methyl-naphthalene-1-carboxylic acid, 7-fluoro-3-methoxycarbonylmethyl-naphthalene-1-carboxylic acid (80 mg) was obtained as a light brown viscous oil. MS cald. for C14H10FO4 262, obsd. (ESI+) [(M+H)+] 263.

Sources & evidence

ORD record
ord-4092a67a77444c4fbdc7628976b8764c
Source dataset
uspto-grants-2012_05
Patent number
US08188090B2

Reaction notes

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