(3-trifluoromethyl-phenoxy)-acetaldehyde → HCID 66734144, compound

HRID 1929674Notes

Reaction equation

HRID 1929674 reaction equation
[CH2:1]([C:3]1[N:4]([CH2:9][CH2:10][NH2:11])[CH:5]=[C:6]([I:8])[N:7]=1)[CH3:2].[F:12][C:13]([F:25])([F:24])[C:14]1[CH:15]=[C:16]([CH:21]=[CH:22][CH:23]=1)[O:17][CH2:18][CH:19]=O>>[CH2:1]([C:3]1[N:4]2[CH2:9][CH2:10][NH:11][CH:19]([CH2:18][O:17][C:16]3[CH:21]=[CH:22][CH:23]=[C:14]([C:13]([F:12])([F:24])[F:25])[CH:15]=3)[C:5]2=[C:6]([I:8])[N:7]=1)[CH3:2]

Participants

3

Reactant 2

HCID 11252687(3-trifluoromethyl-phenoxy)-acetaldehydeHCID 66734063HCID 66734063, compound

Product 1

HCID 66734144HCID 66734144, compound

Procedure

According to the general procedure (GP10), microwave-assisted Pictet-Spengler reaction (60 W; 140° C.; 6.5 bars; 10 min.) between 2-(2-ethyl-4-iodo-imidazol-1-yl)-ethylamine (3.880 mmol) and (3-trifluoromethyl-phenoxy)-acetaldehyde (0.792 g; 3.880 mmol) afforded 3-ethyl-1-iodo-8-(3-trifluoromethyl-phenoxymethyl)-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine.

Sources & evidence

ORD record
ord-127d2da263874f3895574f9cd9cf1ff8
Source dataset
uspto-grants-2012_05
Patent number
US08188082B2

Reaction notes

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