2-(2,4-Dimethyl-1H-imidazol-1-yl)ethanamine → 8-[2-(2,4-Dimethoxyphenyl)ethyl]-1,3-dimethyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine

HRID 1929683Notes

Reaction equation

HRID 1929683 reaction equation
[CH3:1][C:2]1[N:3]([CH2:8][CH2:9][NH2:10])[CH:4]=[C:5]([CH3:7])[N:6]=1.[CH3:11][O:12][C:13]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=1[CH2:21][CH2:22][CH:23]=O>>[CH3:11][O:12][C:13]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=1[CH2:21][CH2:22][CH:23]1[NH:10][CH2:9][CH2:8][N:3]2[C:2]([CH3:1])=[N:6][C:5]([CH3:7])=[C:4]12

Participants

3

Reactant 2

HCID 184607002-(2,4-Dimethyl-1H-imidazol-1-yl)ethanamineHCID 218597283-(2,4-Dimethoxyphenyl)propanal

Product 1

HCID 667331718-[2-(2,4-Dimethoxyphenyl)ethyl]-1,3-dimethyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine

Procedure

Prepared according to the previously described general procedure (GP11) by reaction of 2-(2,4-dimethyl-imidazol-1-yl)-ethylamine with 3-(2,4-dimethoxy-phenyl)-propionaldehyde. LC-MS: tR=0.59 min.; [M+H]+=316 g/mol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d4fddfa731ee4b339982009e5b46cb58
Source dataset
uspto-grants-2012_05
Patent number
US08188082B2

Reaction notes

Loading…