HCID 66733958, compound → HCID 66734283, compound

HRID 1929722Notes

Reaction equation

HRID 1929722 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]2[C:14]([Cl:18])=[N:15][C:16]([Cl:17])=[C:10]2[CH:9]1[CH2:19][CH2:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=1)=O)(C)(C)C>C(Cl)Cl.CO>[Cl:17][C:16]1[N:15]=[C:14]([Cl:18])[N:11]2[CH2:12][CH2:13][NH:8][CH:9]([CH2:19][CH2:20][C:21]3[CH:22]=[CH:23][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:25][CH:26]=3)[C:10]=12

Participants

3

Reactant 1

HCID 66733958HCID 66733958, compound

Product 1

HCID 66734283HCID 66734283, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

According to the general procedure (GP13), Boc-deprotection of 1,3-dichloro-8-[2-(4-trifluoromethyl-phenyl)-ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester (185.7 mg; 0.400 mmol) and purification by FC (DCM/MeOH/25% aq. NH4OH=150/10/1) gave the expected product 1,3-dichloro-8-[2-(4-trifluoromethyl-phenyl)-ethyl]-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine as a yellow oil (121 mg; 0.332 mmol; 83%). LC-MS: tR=0.79 min.; [M+H]+=364.11 g/mol.

Sources & evidence

ORD record
ord-7c649d432c6241ee876bd9683029c1b9
Source dataset
uspto-grants-2012_05
Patent number
US08188082B2

Reaction notes

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