Bis(2-chloroethyl) ether → HCID 70303802, compound

HRID 1929745Notes

Reaction equation

HRID 1929745 reaction equation
[NH2:1][C:2]1[C:24]([C:25](=[O:32])[NH:26][CH:27]2[CH2:31][CH2:30][CH2:29][CH2:28]2)=[C:5]2[N:6]=[CH:7][C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])=[C:9]([C:10]3[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=3)[N:4]2[N:3]=1.Cl[CH2:34][CH2:35][O:36][CH2:37][CH2:38]Cl>>[Cl:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[C:8]1[CH:7]=[N:6][C:5]2[N:4]([N:3]=[C:2]([N:1]3[CH2:38][CH2:37][O:36][CH2:35][CH2:34]3)[C:24]=2[C:25](=[O:32])[NH:26][CH:27]2[CH2:31][CH2:30][CH2:29][CH2:28]2)[C:9]=1[C:10]1[CH:11]=[CH:12][C:13]([Cl:16])=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 8115Bis(2-chloroethyl) etherHCID 67272527HCID 67272527, compound

Product 1

HCID 70303802HCID 70303802, compoundYield 33%

Procedure

The compound obtained in Example 40 and 2-chloroethylether were treated in the same manner as described in Example 43 to obtain 6-(2-chlorophenyl)-7-(4-chlorophenyl)-2-morpholino-3-(N-cyclopentylcarbamoyl)pyrazolo[1,5-a]pyrimidine (23 mg, yield: 33%) as a powder.

Sources & evidence

ORD record
ord-d925109c08804511b529588fb8a85dd2
Source dataset
uspto-grants-2012_05
Patent number
US08188097B2

Reaction notes

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