反应详情

温度

70 °C

1 g of malonic acid and 0.63 g of paraformaldehyde were diluted with 10 ml of 1,3-dioxane, and 4.8 ml of a 2.0M dimethylamine-containing tetrahydrofuran solution was added thereto. The resulting mixture was heated to 70° C. and stirred for one hour. After the reaction terminated, the resulting solution was distilled under a reduced pressure. The resulting residue was crystallized with acetone and filtered under a reduced pressure to obtain the title compound (0.4 g, 32%) in the form of white crystal.

1. additionwas added
2. customAfter the reaction terminated
3. distillationthe resulting solution was distilled under a reduced pressure
4. customThe resulting residue was crystallized with acetone
5. filtrationfiltered under a reduced pressure