Cyclopropanemethanol → 5-(4-Fluorophenyl)-6-cyclopropylmethoxy-nicotinic acid

HRID 1929808Notes

Reaction equation

HRID 1929808 reaction equation
Cl[C:2]1[C:10]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[OH:18][CH2:19][CH:20]1[CH2:22][CH2:21]1>>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:10]2[C:2]([O:18][CH2:19][CH:20]3[CH2:22][CH2:21]3)=[N:3][CH:4]=[C:5]([CH:9]=2)[C:6]([OH:8])=[O:7])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 75644CyclopropanemethanolHCID 463138276-Chloro-5-(4-fluoro-phenyl)-nicotinic acid

Product 1

HCID 211097215-(4-Fluorophenyl)-6-cyclopropylmethoxy-nicotinic acid

Procedure

The title compound was synthesized in analogy to Example 5c, using 6-chloro-5-(4-fluoro-phenyl)-nicotinic acid and (hydroxymethyl)cyclopropane as starting materials, MS (ISP) 286.0 (M−H).

Sources & evidence

ORD record
ord-1d5c3e906541451dba10ae7e4bcda420
Source dataset
uspto-grants-2012_05
Patent number
US08188093B2

Reaction notes

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