2,2,2-Trifluoroethanol → 5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid

HRID 1929810Notes

Reaction equation

HRID 1929810 reaction equation
Cl[C:2]1[C:10]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[F:18][C:19]([F:23])([F:22])[CH2:20][OH:21]>>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([C:10]2[C:2]([O:21][CH2:20][C:19]([F:23])([F:22])[F:18])=[N:3][CH:4]=[C:5]([CH:9]=2)[C:6]([OH:8])=[O:7])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 64092,2,2-TrifluoroethanolHCID 866191836-Chloro-5-(4-chlorophenyl)-3-pyridinecarboxylic acid

Product 1

HCID 666869715-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid

Procedure

The title compound was synthesized in analogy to Example 5c, using 6-chloro-5-(4-chloro-phenyl)-nicotinic acid and 2,2,2-trifluoro-ethanol as starting materials, MS (ISP) 330.3 (M−H).

Sources & evidence

ORD record
ord-783745db3e7541dd92cbbd8adf5f39ec
Source dataset
uspto-grants-2012_05
Patent number
US08188093B2

Reaction notes

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