Dibromomethane → Methyl 5-bromo-6-(4-chlorophenyl)pyrazine-2-carboxylate

HRID 1929842Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1929842
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[N:9][C:8](N)=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[N:6]=1)=[O:4].C(ON=O)CC(C)C.[Br:27]CBr.C[Si](C)(C)Br>>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([Br:27])=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[N:6]=1)=[O:4]

Komponenten

5

Edukt 4

HCID 3024DibromomethaneHCID 8053Isoamyl NitriteHCID 76113BromotrimethylsilaneHCID 675046835-Amino-6-(4-chloro-phenyl)-pyrazine-2-carboxylic acid methyl ester

Produkt 1

HCID 86619571Methyl 5-bromo-6-(4-chlorophenyl)pyrazine-2-carboxylate

Versuchsvorschrift

The title compound was synthesized in analogy to the procedure described for the preparation of Example 36b, using 5-amino-6-(4-chloro-phenyl)-pyrazine-2-carboxylic acid methyl ester as starting material and isoamylnitrite, dibromomethane and trimethylbromosilane as reagents to give the title compound which was used in the next step without further purification.

Aufarbeitung

  1. customThe title compound was synthesized in analogy to the procedure
  2. customdescribed for the preparation of Example 36b

Quellen und Nachweise

ORD-Eintrag
ord-169dd4e263434377b1ed0f71a0871576
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08188093B2

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