HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dibromomethane → Methyl 5-bromo-6-(4-chlorophenyl)pyrazine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dibromomethane | HCID 3024 | — |
| Reactant | Isoamyl Nitrite | HCID 8053 | — |
| Reactant | Bromotrimethylsilane | HCID 76113 | — |
| Reactant | 5-Amino-6-(4-chloro-phenyl)-pyrazine-2-carboxylic acid methyl ester | HCID 67504683 | — |
| Product | Methyl 5-bromo-6-(4-chlorophenyl)pyrazine-2-carboxylate | HCID 86619571 | — |
Reaction Steps
The title compound was synthesized in analogy to the procedure described for the preparation of Example 36b, using 5-amino-6-(4-chloro-phenyl)-pyrazine-2-carboxylic acid methyl ester as starting material and isoamylnitrite, dibromomethane and trimethylbromosilane as reagents to give the title compound which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188093B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-169dd4e263434377b1ed0f71a0871576 |
| Source note | uspto-grants-2012_05 |