HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorophenol → 5-(2-Chloro-phenoxy)-6-(4-chloro-phenyl)-pyrazine-2-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorophenol | HCID 7245 | — |
| Reactant | 5-bromo-6-(4-chloro-phenyl)-pyrazine-2-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexyl)-amide | HCID 86616972 | — |
| Product | 5-(2-Chloro-phenoxy)-6-(4-chloro-phenyl)-pyrazine-2-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexyl)-amide | HCID 24857248 | — |
Reaction Steps
The title compound was synthesized in analogy to the procedure described for the preparation of Example 36 c, using 5-bromo-6-(4-chloro-phenyl)-pyrazine-2-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexyl)-amide, and chlorophenol (commercially available) as starting materials to give the title compound as a white solid. mp.: 154-155° C., MS (ISP): 458.3, 460.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188093B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-2785ad4a601443e580f41d1a38602d1e |
| Source note | uspto-grants-2012_05 |