Cyclopropylacetylene → HCID 49802549, compound

HRID 1929902Notes

Reaction equation

HRID 1929902 reaction equation
[CH:1]1([C@:4]([OH:24])([CH3:23])[CH2:5][NH:6][C:7]([C:9]2[CH:14]=[N:13][C:12](Br)=[C:11]([C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=3)[N:10]=2)=[O:8])[CH2:3][CH2:2]1.[C:25]([CH:27]1[CH2:29][CH2:28]1)#[CH:26]>>[CH:1]1([C@:4]([OH:24])([CH3:23])[CH2:5][NH:6][C:7]([C:9]2[CH:14]=[N:13][C:12]([CH2:26][CH2:25][CH:27]3[CH2:29][CH2:28]3)=[C:11]([C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=3)[N:10]=2)=[O:8])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 138823CyclopropylacetyleneHCID 86616978HCID 86616978, compound

Product 1

HCID 49802549HCID 49802549, compound

Procedure

The title compound was synthesized in analogy to Example 117, using 5-bromo-6-(4-chloro-phenyl)-pyrazine-2-carboxylic acid ((R)-2-cyclopropyl-2-hydroxy-propyl)-amide and ethynylcyclopropane as starting materials to yield the product as colorless foam, MS (ISP) 400.1 (M+H)+.

Sources & evidence

ORD record
ord-787ccdf520464c47a35467efcec04889
Source dataset
uspto-grants-2012_05
Patent number
US08188093B2

Reaction notes

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