Toluene → Tert-butyl 4-(6-(1-(4-(trifluoromethyl)phenyl)piperidin-4-yloxy)quinoline-3-carboxamido)piperidine-1-carboxylate
Reaction equation
[CH3:78][c:79]1[cH:80][cH:81][cH:82][cH:83][cH:84]1.[F:42][C:43]([c:44]1[cH:45][cH:46][c:47]([N:50]2[CH2:51][CH2:52][CH:53]([OH:56])[CH2:54][CH2:55]2)[cH:48][cH:49]1)([F:57])[F:58].[O:28]=[C:29]([O:30][CH:31]([CH3:32])[CH3:33])[N:34]=[N:35][C:36]([O:37][CH:38]([CH3:39])[CH3:40])=[O:41].[OH:1][c:2]1[cH:3][c:4]2[cH:5][c:6]([C:12](=[O:13])[NH:14][CH:15]3[CH2:16][CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]3)[cH:7][n:8][c:9]2[cH:10][cH:11]1.[c:59]1([P:60]([c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)[c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)[cH:73][cH:74][cH:75][cH:76][cH:77]1>>[O:1]([c:2]1[cH:3][c:4]2[cH:5][c:6]([C:12](=[O:13])[NH:14][CH:15]3[CH2:16][CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]3)[cH:7][n:8][c:9]2[cH:10][cH:11]1)[CH:53]1[CH2:52][CH2:51][N:50]([c:47]2[cH:46][cH:45][c:44]([C:43]([F:42])([F:57])[F:58])[cH:49][cH:48]2)[CH2:55][CH2:54]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-3bc8129a9cee4f0da1be543222a7b15a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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