6-Iodo-3-isopropyl-[1,2,4]triazolo[4,3-b]pyridazine → HCID 57929864, compound

HRID 1930069Notes

Reaction equation

HRID 1930069 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH:11]([CH3:13])[CH3:12])=[N:9][N:10]=2)[N:7]=1.[F:14][C:15]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=1[C:22]1[C:26](I)=[C:25]([CH3:28])[O:24][N:23]=1>>[F:14][C:15]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=1[C:22]1[C:26]([C:2]2[CH:3]=[CH:4][C:5]3[N:6]([C:8]([CH:11]([CH3:13])[CH3:12])=[N:9][N:10]=3)[N:7]=2)=[C:25]([CH3:28])[O:24][N:23]=1

Participants

3

Reactant 2

HCID 579298936-Iodo-3-isopropyl-[1,2,4]triazolo[4,3-b]pyridazineHCID 57929922HCID 57929922, compound

Product 1

HCID 57929864HCID 57929864, compoundYield 22.1%

Procedure

6-Iodo-3-isopropyl-[1,2,4]triazolo[4,3-b]pyridazine (0.400 g, 1.25 mmol, Preparation #H.1) and 3-(2,4-difluorophenyl)-4-iodo-5-methylisoxazole (0.360 g, 1.25 mmol) were coupled using General Procedure I.1 to provide the title compound (0.098 g, 22%): LC/MS (Table 1, Method g) Rt=2.16 min; MS m/z: 356.0 (M+H)+.

Sources & evidence

ORD record
ord-123cb68a344942b7b6597c8772d884da
Source dataset
uspto-grants-2012_05
Patent number
US08188083B2

Reaction notes

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