3-Chloro-4-fluorobenzaldehyde → 7-Chloro-6-fluoroisoquinoline

HRID 1930198Notes

Reaction equation

HRID 1930198 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH:5]=O.FC1C=C2C(=CC=1)C=[N:17][CH:16]=[CH:15]2>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:7]([CH:15]=[CH:16][N:17]=[CH:5]2)=[CH:8][C:9]=1[F:10]

Participants

3

Reactant 2

HCID 5938663-Chloro-4-fluorobenzaldehydeHCID 218898476-Fluoroisoquinoline

Product 1

HCID 534189227-Chloro-6-fluoroisoquinoline

Procedure

Starting from 3-chloro-4-fluoro-benzaldehyde, the title compound was prepared by the same reaction sequence as used for the synthesis of 6-fluoro-isoquinoline (3). Rt=0.77 min (Method A). Detected mass: 182.1/184.1 (M+H+).

Sources & evidence

ORD record
ord-0555398550ce4238a785fb9fa39938a4
Source dataset
uspto-grants-2012_05
Patent number
US08188117B2

Reaction notes

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