6-Fluoro-7-bromoisoquinoline → 7-Bromo-6-fluoro-isoquinoline 2-oxide

HRID 1930218Notes

Reaction equation

HRID 1930218 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[CH:9]2)=[CH:4][C:3]=1[F:12].ClC1C=C2C(C=C[N+]([O-:24])=C2)=CC=1F>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N+:8]([O-:24])=[CH:9]2)=[CH:4][C:3]=1[F:12]

Participants

3

Reactant 2

HCID 534029646-Fluoro-7-bromoisoquinolineHCID 598182547-Chloro-6-fluoro-isoquinoline 2-oxide

Product 1

HCID 598182517-Bromo-6-fluoro-isoquinoline 2-oxide

Procedure

Starting from 7-bromo-6-fluoro-isoquinoline (15), the title compound was prepared following the method described for 7-chloro-6-fluoro-isoquinoline 2-oxide (5). Rt=0.93 min (Method C). Detected mass: 242.2/244.2 (M+H+).

Sources & evidence

ORD record
ord-f30c45a39b184f739854cbd83f42d47a
Source dataset
uspto-grants-2012_05
Patent number
US08188117B2

Reaction notes

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