HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Bromo-6-(piperidin-4-yloxy)-2H-isoquinolin-1-one → 7-Ethyl-6-(piperidin-4-yloxy)-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Bromo-6-(piperidin-4-yloxy)-2H-isoquinolin-1-one | HCID 57652347 | — |
| Reactant | 4-[7-Ethyl-2-(4-methoxy-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-yloxy]-piperidine-1-carboxylic acid tert-butyl ester | HCID 57652598 | — |
| Product | 7-Ethyl-6-(piperidin-4-yloxy)-2H-isoquinolin-1-one | HCID 57652513 | — |
Reaction Steps
4-[7-Ethyl-2-(4-methoxy-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-yloxy]-piperidine-1-carboxylic acid tert-butyl ester (319) is deprotected following the method described for 7-bromo-6-(piperidin-4-yloxy)-2H-isoquinolin-1-one (17). Final purification by preparative HPLC delivers the title compound as trifluoroacetate. Rt=0.92 min (Method A). Detected mass: 273.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188117B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-2177f1068d1e4ccc87b636680d9720b4 |
| Source note | uspto-grants-2012_05 |