反应详情

MnO2 (39 g, 448 mmol) was added to a solution of (6-chloro-4-phenylamino-pyridin-3-yl)-methanol (13 g, 56 mmol) in CH2Cl2 (100 ml) and the mixture was stirred at RT overnight. The solids was removed by filtration and the filtrate was concentrated to give 6-chloro-4-(phenylamino)nicotinaldehyde (11 g, 86% yield). 1H-NMR (400 MHz, DMSO-d6): δ 10.18 (s, 1H), 9.99 (s, 1 H), 8.62 (s, 1 H), 7.49-7.31 (m, 5 H), 6.80 (s, 1 H).

1. customThe solids was removed by filtration
2. concentrationthe filtrate was concentrated