HuagongsheHuagongshe Chemistry Print Report · For research reference only
(6-Chloro-4-(phenylamino)pyridin-3-yl)methanol → 6-Chloro-4-phenylamino-pyridine-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (6-Chloro-4-(phenylamino)pyridin-3-yl)methanol | HCID 86620159 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-Chloro-4-phenylamino-pyridine-3-carbaldehyde | HCID 59212348 | 86% |
Reaction Steps
MnO2 (39 g, 448 mmol) was added to a solution of (6-chloro-4-phenylamino-pyridin-3-yl)-methanol (13 g, 56 mmol) in CH2Cl2 (100 ml) and the mixture was stirred at RT overnight. The solids was removed by filtration and the filtrate was concentrated to give 6-chloro-4-(phenylamino)nicotinaldehyde (11 g, 86% yield). 1H-NMR (400 MHz, DMSO-d6): δ 10.18 (s, 1H), 9.99 (s, 1 H), 8.62 (s, 1 H), 7.49-7.31 (m, 5 H), 6.80 (s, 1 H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188113B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-ebf072c8500f416f8157b4968a82ffd2 |
| Source note | uspto-grants-2012_05 |