HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-cyano-4-fluoro-5-nitrophenylacetate → Ethyl 2-(5-amino-2-cyano-4-fluorophenyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-cyano-4-fluoro-5-nitrophenylacetate | HCID 69088377 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Ethyl 2-(5-amino-2-cyano-4-fluorophenyl)acetate | HCID 68982767 | 81% |
Reaction Steps
To a solution of ethyl 2-(2-cyano-4-fluoro-5-nitrophenyl)acetate in methanol and EtOAc (1:1, 10 mL) was added 10% Pd/C. The solution was stirred under H2 (1 arm) at RT for 3 days. The solution was filtered and evaporated to obtain ethyl 2-(5-amino-2-cyano-4-fluorophenyl)acetate (0.21 g, 81% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188113B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-23f82806e2494fd091ad75ccf62a394e |
| Source note | uspto-grants-2012_05 |