Lithium hydroxide, monohydrate → HCID 66729176, compound

HRID 1930377Notes

Reaction equation

HRID 1930377 reaction equation
[C:1]([C:5]1[N:10]=[C:9](C2C=CC=C(F)C=2)[C:8]([C:18]([O-:20])=[O:19])=[CH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].O[Li].[OH2:23]>>[C:1]([C:5]1[N:10]=[C:9]([N:6]2[CH2:7][CH2:8][O:23][CH2:1][CH2:5]2)[C:8]([C:18]([OH:20])=[O:19])=[CH:7][N:6]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 86620167HCID 86620167, compound

Product 1

HCID 66729176HCID 66729176, compoundYield 194.8%

Procedure

Using a procedure to Example B40, 2-tert-butyl-4-(3-fluorophenyl)pyrimidine-5-carboxylate (0.27 g, 0.89 mmol) was treated with LiOH—H2O (86 mg, 3.57 mmol) to afford 2-tert-butyl-4-morpholinopyrimidine-5-carboxylic acid (0.23 g, 92% yield). MS (ESI) m/z: 275.0 (M+H+).

Sources & evidence

ORD record
ord-f078888f8e0a4944946a113eca555a54
Source dataset
uspto-grants-2012_05
Patent number
US08188113B2

Reaction notes

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