HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium hydroxide, monohydrate → 2-Tert-butyl-4-(pyridin-3-yl)pyrimidine-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Ethyl 2-tert-butyl-4-(pyridin-3-yl)pyrimidine-5-carboxylate | HCID 68983241 | — |
| Product | 2-Tert-butyl-4-(pyridin-3-yl)pyrimidine-5-carboxylic acid | HCID 68984106 | 72% |
Reaction Steps
Using a procedure analogous to Example B39, ethyl 2-tert-butyl-4-(pyridin-3-yl)pyrimidine-5-carboxylate (0.17 g, 0.60 mmol) was treated with LiOH.H2O (57 mg, 2.38 mmol) to afford 2-tert-butyl-4-(pyridin-3-yl)pyrimidine-5-carboxylic acid (0.11 g, 72% yield). MS (ESI) m/z: 258.0 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188113B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-60cf297fca73417e9e5fe90b4900f634 |
| Source note | uspto-grants-2012_05 |