反应详情

To a solution of 4-(2-methyl-1H-imidazol-1-yl)aniline (2 g, 11.55 mmol) in ethanol (25 mL) was added cyanamide (0.728 g, 17.32 mmol) and hydrochloric acid (1.422 mL, 17.32 mmol). The reaction mixture was refluxed for 4 h. An additional 1 eq of hydrochloric acid (1.422 ml, 17.32 mmol) was added and precipitation occurred. The precipitated product was filtered off and washed with DCM to give 1-(4-(2-methyl-1H-imidazol-1-yl)phenyl)guanidine (1.600 g, 64.4%). MS (ESI+)/(ESI−) m/z 216/214

1. temperatureThe reaction mixture was refluxed for 4 h
2. customprecipitation
3. filtrationThe precipitated product was filtered off
4. washwashed with DCM