Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 59333748 | HCID 59333748 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 59333755 | HCID 59333755 | — |
Reaction Steps
tert-Butyl 4-((2-hydroxyethyl)(phenyl)amino)-2-(4-(1-methyl-1H-pyrazol-4-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (882 mg, 1.63 mmol) was dissolved in methanol (5 mL). Hydrochloric acid (0.136 mL, 1.63 mmol) was added and the reaction mixture was stirred at 70° C. for 1 h. The solvent was evaporated under reduced pressure and the crude was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08188101B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-aa9dc0e83d0c47c1a890503fb7b77013 |
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| Source note | uspto-grants-2012_05 |
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