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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1930584Generated: November 3, 2026

Hydrochloric Acid → HCID 59333755, compound

https://huagongshe.com/reaction/1930584

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 59333748HCID 59333748—
SolventMethanolHCID 887—
ProductHCID 59333755HCID 59333755—

Reaction Conditions

Temperature70 °C

Reaction Steps

tert-Butyl 4-((2-hydroxyethyl)(phenyl)amino)-2-(4-(1-methyl-1H-pyrazol-4-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (882 mg, 1.63 mmol) was dissolved in methanol (5 mL). Hydrochloric acid (0.136 mL, 1.63 mmol) was added and the reaction mixture was stirred at 70° C. for 1 h. The solvent was evaporated under reduced pressure and the crude was used in the next step without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08188101B2
Source datasetuspto-grants-2012_05
ORD IDord-aa9dc0e83d0c47c1a890503fb7b77013
Source noteuspto-grants-2012_05