Hydrochloric Acid → HCID 59333755, compound

HRID 1930584Notes

Reaction equation

HRID 1930584 reaction equation
[OH:1][CH2:2][CH2:3][N:4]([C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[C:5]1[C:6]2[CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25][CH2:24][C:7]=2[N:8]=[C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:19]=[N:20][N:21]([CH3:23])[CH:22]=3)=[CH:14][CH:13]=2)[N:10]=1.Cl>CO>[CH3:23][N:21]1[CH:22]=[C:18]([C:15]2[CH:14]=[CH:13][C:12]([NH:11][C:9]3[N:10]=[C:5]([N:4]([C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[CH2:3][CH2:2][OH:1])[C:6]4[CH2:27][NH:26][CH2:25][CH2:24][C:7]=4[N:8]=3)=[CH:17][CH:16]=2)[CH:19]=[N:20]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59333748HCID 59333748, compound

Product 1

HCID 59333755HCID 59333755, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
70 °C

Procedure

tert-Butyl 4-((2-hydroxyethyl)(phenyl)amino)-2-(4-(1-methyl-1H-pyrazol-4-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (882 mg, 1.63 mmol) was dissolved in methanol (5 mL). Hydrochloric acid (0.136 mL, 1.63 mmol) was added and the reaction mixture was stirred at 70° C. for 1 h. The solvent was evaporated under reduced pressure and the crude was used in the next step without further purification.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe crude was used in the next step without further purification

Sources & evidence

ORD record
ord-aa9dc0e83d0c47c1a890503fb7b77013
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

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