反应详情

1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate (1 g, 3.89 mmol), 1-(4-bromophenyl)guanidine (0.832 g, 3.89 mmol) and sodium ethoxide (0.264 g, 3.89 mmol) in ethanol (8 mL) were heated to 100° C. in a microwave reactor for 15 minutes. The reaction mixture was allowed to reach room temperature, the solid obtained was filtered and washed with cold ethanol and dried in a vacuum oven yielding tert-butyl 2-(4-bromophenylamino)-4-hydroxy-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (1.45 g, 72%). The compound was used in the next step without purification. MS (ESI) (M+H) m/z 423

1. customto reach room temperature
2. customthe solid obtained
3. filtrationwas filtered
4. washwashed with cold ethanol
5. customdried in a vacuum oven