Morpholine → HCID 21717544, compound

HRID 1930594Notes

Reaction equation

HRID 1930594 reaction equation
O=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>C1(C)C=CC=CC=1>[O:18]1[CH2:19][CH2:20][N:15]([C:2]2[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH:3]=2)[CH2:16][CH2:17]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 21717544HCID 21717544, compoundYield 99.5%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

tert-Butyl 4-oxopiperidine-1-carboxylate (5 g, 25.09 mmol) was dissolved in toluene (25 mL). Morpholine (2.186 mL, 25.09 mmol) was added and the reaction mixture was heated overnight in a atmosphere of argon in a Dean-Stark reflux apparatus. The mixture was allowed to reach room temperature and it was evaporated to dryness yielding tert-butyl 4-morpholino-5,6-dihydropyridine-1(2H)-carboxylate (6.70 g, 99%).

Workup

  1. temperaturethe reaction mixture was heated overnight in a atmosphere of argon in a Dean-Stark
  2. temperaturereflux apparatus
  3. customto reach room temperature
  4. customit was evaporated to dryness

Sources & evidence

ORD record
ord-cd98bbda0d5545a692ea1b0d8477d86b
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

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