HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → HCID 21717544, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 21717544 | HCID 21717544 | 99.5% |
Reaction Steps
tert-Butyl 4-oxopiperidine-1-carboxylate (5 g, 25.09 mmol) was dissolved in toluene (25 mL). Morpholine (2.186 mL, 25.09 mmol) was added and the reaction mixture was heated overnight in a atmosphere of argon in a Dean-Stark reflux apparatus. The mixture was allowed to reach room temperature and it was evaporated to dryness yielding tert-butyl 4-morpholino-5,6-dihydropyridine-1(2H)-carboxylate (6.70 g, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188101B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-cd98bbda0d5545a692ea1b0d8477d86b |
| Source note | uspto-grants-2012_05 |