Tetrahydrothiopyran-4-one → 3-(2-(4-Fluorophenyl)acetyl)dihydro-2H-thiopyran-4(3H)-one

HRID 1930601Notes

Reaction equation

HRID 1930601 reaction equation
[S:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1.[F:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16](Cl)=[O:17])=[CH:11][CH:10]=1>>[F:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([CH:3]2[C:4](=[O:7])[CH2:5][CH2:6][S:1][CH2:2]2)=[O:17])=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 66173Tetrahydrothiopyran-4-oneHCID 37449884-Fluorophenylacetyl chloride

Product 1

HCID 593337083-(2-(4-Fluorophenyl)acetyl)dihydro-2H-thiopyran-4(3H)-oneYield 78%

Procedure

3-(2-(4-Fluorophenyl)acetyl)dihydro-2H-thiopyran-4(3H)-one (508 mg, 78%) was obtained from tetrahydrothiopyran-4-one and 4-fluorophenylacetyl chloride by the general procedure for the preparation of diketones. MS (ES+) m/z 253.1 (M+H)+

Sources & evidence

ORD record
ord-f2fe3d4b049248e9a66d1db1abbcf69e
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

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