HRID1930606

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1ccc(CC(=O)C2CN(C(=O)OC(C)(C)C)CCC2=O)cc1

HCID59333812

未命名化合物

HCID178432900

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(Cc2nc(Nc3ccc(-n4ccnc4C)cc3)nc3c2CN(C(=O)OC(C)(C)C)CC3)cc1

HCID59333746

未命名化合物

收率 44%

PROCEDURE

实验过程

tert-Butyl 2-(4-(2-methyl-1H-imidazol-1-yl)phenyl amino)-4-(4-methylbenzyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (236 mg, 44%) was synthesised from tert-butyl 4-oxo-3-(2-p-tolylacetyl)piperidine-1-carboxylate and 1-(4-(2-methyl-1H-imidazol-1-yl)phenyl)guanidine (Example 41c) according to the general procedure for synthesis of pyrimidines. MS (ES+) m/z 511.1 (M+H)+

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-896451ef61a64e2cba49bb2f62523a68
来源数据集: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08188101B2
来源说明: uspto-grants-2012_05

反应 SMILES

O=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH:3]1[C:15](=O)[CH2:16][C:17]1[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=1.[CH3:25][C:26]1[N:27]([C:31]2[CH:36]=[CH:35][C:34]([NH:37][C:38]([NH2:40])=[NH:39])=[CH:33][CH:32]=2)[CH:28]=[CH:29][N:30]=1>>[CH3:25][C:26]1[N:27]([C:31]2[CH:32]=[CH:33][C:34]([NH:37][C:38]3[N:39]=[C:15]([CH2:16][C:17]4[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=4)[C:3]4[CH2:4][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:6][CH2:7][C:2]=4[N:40]=3)=[CH:35][CH:36]=2)[CH:28]=[CH:29][N:30]=1