Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tert-butyl 4-oxo-3-(2-p-tolylacetyl)piperidine-1-carboxylate → tert-Butyl 2-(4-(2-methyl-1H-imidazol-1-yl)phenyl amino)-4-(4-methylbenzyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tert-butyl 4-oxo-3-(2-p-tolylacetyl)piperidine-1-carboxylate | HCID 59333812 | — |
| 반응물 | HCID 178432900 | HCID 178432900 | — |
| 생성물 | tert-Butyl 2-(4-(2-methyl-1H-imidazol-1-yl)phenyl amino)-4-(4-methylbenzyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate | HCID 59333746 | 44% |
반응 단계
tert-Butyl 2-(4-(2-methyl-1H-imidazol-1-yl)phenyl amino)-4-(4-methylbenzyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (236 mg, 44%) was synthesised from tert-butyl 4-oxo-3-(2-p-tolylacetyl)piperidine-1-carboxylate and 1-(4-(2-methyl-1H-imidazol-1-yl)phenyl)guanidine (Example 41c) according to the general procedure for synthesis of pyrimidines. MS (ES+) m/z 511.1 (M+H)+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08188101B2 |
| 출처 데이터셋 | uspto-grants-2012_05 |
| ORD ID | ord-896451ef61a64e2cba49bb2f62523a68 |
| 출처 메모 | uspto-grants-2012_05 |