tert-Butyl 4-oxopiperidine-1-carboxylate → HCID 59333721, compound

HRID 1930610Notes

Reaction equation

HRID 1930610 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.[F:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[CH2:22][C:23](Cl)=[O:24]>>[F:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[CH2:22][C:23]([CH:7]1[C:2](=[O:1])[CH2:3][CH2:4][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:6]1)=[O:24]

Participants

3

Reactant 2

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 140040112-(2-Fluorophenyl)acetyl chloride

Product 1

HCID 59333721HCID 59333721, compoundYield 52%

Procedure

tert-Butyl 3-(2-(2-fluorophenyl)acetyl)-4-oxopiperidine-1-carboxylate (295 mg, 52%) was synthesised from tert-butyl 4-oxopiperidine-1-carboxylate and 2-(2-fluorophenyl)acetyl chloride according to the general procedure for the preparation of diketones. MS (ES−) m/z 334.1(M−H)−

Sources & evidence

ORD record
ord-a0bf223f0c2a49ff98a7a1cf0230d939
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

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