HCID 59333808, compound → HCID 59333691, compound

HRID 1930612Notes

Reaction equation

HRID 1930612 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10]([CH:12]2[C:17](=O)[CH2:16][CH2:15][N:14]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:13]2)=O)[CH:6]=[CH:7][CH:8]=1.[CH3:26][C:27]1[N:28]([C:32]2[CH:37]=[CH:36][C:35]([NH:38][C:39]([NH2:41])=[NH:40])=[CH:34][CH:33]=2)[CH:29]=[CH:30][N:31]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][CH:8]=1)[CH2:9][C:10]1[C:12]2[CH2:13][N:14]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][CH2:16][C:17]=2[N:41]=[C:39]([NH:38][C:35]2[CH:36]=[CH:37][C:32]([N:28]3[CH:29]=[CH:30][N:31]=[C:27]3[CH3:26])=[CH:33][CH:34]=2)[N:40]=1

Participants

3

Reactant 2

HCID 59333808HCID 59333808, compoundHCID 178432900HCID 178432900, compound

Product 1

HCID 59333691HCID 59333691, compoundYield 62%

Procedure

tert-Butyl 4-(3-methoxybenzyl)-2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (373 mg, 62%) was synthesised from tert-butyl 3-(2-(3-methoxyphenyl)acetyl)-4-oxopiperidine-1-carboxylate and 1-(4-(2-methyl-1H-imidazol-1-yl)phenyl)guanidine (Example 41c) according to the general procedure for synthesis of pyrimidines. MS (ES+) m/z 527.1 (M+H)+

Sources & evidence

ORD record
ord-351d8874714c46239eef7776bb9c7232
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

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