tert-Butyl 4-oxopiperidine-1-carboxylate → Tert-butyl 3-(2-cyclopentylacetyl)-4-oxopiperidine-1-carboxylate

HRID 1930617Notes

Reaction equation

[O:1]=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.[CH:15]1([CH2:20][C:21](Cl)=[O:22])[CH2:19][CH2:18][CH2:17][CH2:16]1>>[CH:15]1([CH2:20][C:21]([CH:7]2[C:2](=[O:1])[CH2:3][CH2:4][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:6]2)=[O:22])[CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

Reactant 2

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

HCID 3485182Cyclopentylacetyl chloride

Product 1

HCID 59333704Tert-butyl 3-(2-cyclopentylacetyl)-4-oxopiperidine-1-carboxylateYield 59%

Procedure

tert-Butyl 3-(2-cyclopentylacetyl)-4-oxopiperidine-1-carboxylate (311 mg, 59%) was synthesised from tert-butyl 4-oxopiperidine-1-carboxylate and 2-cyclopentylacetyl chloride according to the general procedure for the preparation of diketones. MS (ES−) m/z 308.1 (M−H)−

Sources & evidence

ORD record: ord-b1880c95c18f4d8dbce6b41865567530
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188101B2

Reaction notes

Loading…