Glycolaldehyde → HCID 46199110, compound

HRID 1930618Notes

Reaction equation

HRID 1930618 reaction equation
[F:1][C:2]1[CH:31]=[CH:30][CH:29]=[CH:28][C:3]=1[CH2:4][C:5]1[C:6]2[CH2:27][NH:26][CH2:25][CH2:24][C:7]=2[N:8]=[C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([N:18]3[CH:22]=[CH:21][N:20]=[C:19]3[CH3:23])=[CH:14][CH:13]=2)[N:10]=1.[CH:32](=O)[CH2:33][OH:34]>>[F:1][C:2]1[CH:31]=[CH:30][CH:29]=[CH:28][C:3]=1[CH2:4][C:5]1[C:6]2[CH2:27][N:26]([CH2:32][CH2:33][OH:34])[CH2:25][CH2:24][C:7]=2[N:8]=[C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([N:18]3[CH:22]=[CH:21][N:20]=[C:19]3[CH3:23])=[CH:16][CH:17]=2)[N:10]=1

Participants

3

Reactant 2

HCID 756GlycolaldehydeHCID 59333770HCID 59333770, compound

Product 1

HCID 46199110HCID 46199110, compoundYield 4.5%

Procedure

2-(4-(2-Fluorobenzyl)-2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethanol (4.7 mg, 4.5%) was synthesised from 4-(2-fluorobenzyl)-N-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine (Example 52a) and glycolaldehyde according to the general procedure for reductive amination. MS (ES+) m/z 459.3 (M+H)+

Sources & evidence

ORD record
ord-6f5a29ff95c143d98f799e0cc5875d7d
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

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