Acetic Anhydride → HCID 46199113, compound

HRID 1930621Notes

Reaction equation

[CH3:1][C:2]1[N:3]([C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14]3[N:15]=[C:16]([CH2:24][C:25]4[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][CH:26]=4)[C:17]4[CH2:23][NH:22][CH2:21][CH2:20][C:18]=4[N:19]=3)=[CH:9][CH:8]=2)[CH:4]=[CH:5][N:6]=1.[C:32](OC(=O)C)(=[O:34])[CH3:33]>>[CH3:1][C:2]1[N:3]([C:7]2[CH:8]=[CH:9][C:10]([NH:13][C:14]3[N:15]=[C:16]([CH2:24][C:25]4[CH:26]=[CH:27][C:28]([CH3:31])=[CH:29][CH:30]=4)[C:17]4[CH2:23][N:22]([C:32](=[O:34])[CH3:33])[CH2:21][CH2:20][C:18]=4[N:19]=3)=[CH:11][CH:12]=2)[CH:4]=[CH:5][N:6]=1

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 59333774HCID 59333774, compound

Product 1

HCID 46199113HCID 46199113, compoundYield 10.6%

Procedure

1-(2-(4-(2-Methyl-1H-imidazol-1-yl)phenylamino)-4-(4-methylbenzyl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethanone (11.3 mg, 10.6%) was synthesised from N-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-4-(4-methylbenzyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine (Example 50a) and acetic anhydride according to the general procedure for N-acetylation. MS (ES+) m/z 453.2 (M+H)+

Sources & evidence

ORD record: ord-f518407babb8449091535d55009514f0
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188101B2

Reaction notes

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