Hydrochloric Acid → N2-(4-(Oxazol-5-yl)phenyl)-N4-((tetrahydro-2H-pyran-4-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

HRID 1930674Notes

Reaction equation

[O:1]1[C:5]([C:6]2[CH:11]=[CH:10][C:9]([NH:12][C:13]3[N:14]=[C:15]([NH:30][CH2:31][CH:32]4[CH2:37][CH2:36][O:35][CH2:34][CH2:33]4)[C:16]4[CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19][C:17]=4[N:18]=3)=[CH:8][CH:7]=2)=[CH:4][N:3]=[CH:2]1.Cl>CO>[O:1]1[C:5]([C:6]2[CH:7]=[CH:8][C:9]([NH:12][C:13]3[N:14]=[C:15]([NH:30][CH2:31][CH:32]4[CH2:33][CH2:34][O:35][CH2:36][CH2:37]4)[C:16]4[CH2:22][NH:21][CH2:20][CH2:19][C:17]=4[N:18]=3)=[CH:10][CH:11]=2)=[CH:4][N:3]=[CH:2]1

Participants

Conditions

Temperature: 80 °C

Procedure

tert-Butyl 2-(4-(oxazol-5-yl)phenylamino)-4-((tetrahydro-2H-pyran-4-yl)methylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (330 mg, 0.65 mmol) was dissolved in methanol (3 mL). Hydrochloric acid (0.020 mL, 0.65 mmol) was added and the reaction mixture was stirred at 80° C. for 30 minutes. The solvent was evaporated and the crude was used as such in the subsequent step. MS (ES+) m/z 407.2 (M+H)+

Workup

customThe solvent was evaporated

Sources & evidence

ORD record: ord-dc53bc10233f452c85838cbf90dbd90c
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188101B2

Reaction notes

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