Trifluoroacetic acid → HCID 59333717, compound

HRID 1930687Notes

Reaction equation

HRID 1930687 reaction equation
FC(F)(F)C(O)=O.[CH3:8][O:9][C:10]1[CH:11]=[C:12]([NH:22][C:23]2[N:24]=[C:25]([CH2:40][C:41]3[CH:46]=[CH:45][CH:44]=[C:43]([O:47][CH3:48])[CH:42]=3)[C:26]3[CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29][C:27]=3[N:28]=2)[CH:13]=[CH:14][C:15]=1[N:16]1[CH:20]=[C:19]([CH3:21])[N:18]=[CH:17]1>ClCCl>[CH3:8][O:9][C:10]1[CH:11]=[C:12]([NH:22][C:23]2[N:24]=[C:25]([CH2:40][C:41]3[CH:46]=[CH:45][CH:44]=[C:43]([O:47][CH3:48])[CH:42]=3)[C:26]3[CH2:32][NH:31][CH2:30][CH2:29][C:27]=3[N:28]=2)[CH:13]=[CH:14][C:15]=1[N:16]1[CH:20]=[C:19]([CH3:21])[N:18]=[CH:17]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67423402HCID 67423402, compound

Product 1

HCID 59333717HCID 59333717, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (2 mL, 26.05 mmol) in dichloromethane (2 mL) was added to tert-butyl 2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-4-(3-methoxybenzyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (14 mg, 0.03 mmol) and stirred at rt for 1 hour. The solvents were removed under reduced pressure and the product was used without further purification. MS (ES+) m/z 457.3 (M+H)+

Workup

  1. customThe solvents were removed under reduced pressure
  2. customthe product was used without further purification

Sources & evidence

ORD record
ord-7e668a1bb9dc4e9b9547a609a2911752
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

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