反应详情

温度

130 °C

tert-Butyl 3-(2-(2-fluorophenyl)acetyl)-4-oxopiperidine-1-carboxylate, (0.88 mmol) together with 1 eq 1-(4-(2-methyl-1H-imidazol-1-yl)phenyl)guanidine and 2 eq of potassium carbonate were slurrified in 4 ml EtOH. The reactions were heated in the microwave oven to 130° C. for 3 h. DCM and water were added and the organic phases were separated, dried with MgSO4 and the solvent was removed under reduced pressure tert-butyl 4-(2-fluorobenzyl)-2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (292 mg, 65%).

1. customthe organic phases were separated
2. dry with materialdried with MgSO4
3. customthe solvent was removed under reduced pressure tert-butyl 4-(2-fluorobenzyl)-2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (292 mg, 65%)