Thionyl Chloride → 2-(2-Fluorophenyl)acetyl chloride

HRID 1930693Notes

Reaction equation

HRID 1930693 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=O.S(Cl)([Cl:14])=O>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([Cl:14])=[O:11]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 67979Benzeneacetic acid, 2-fluoro-

Product 1

HCID 140040112-(2-Fluorophenyl)acetyl chloride

Procedure

2-(2-Fluorophenyl)acetic acid, (1.7 mmol) was dissolved in thionyl chloride (0.372 ml, 5.10 mmol) and heated to reflux for 1 h. The reaction was cooled and the excess thionyl chloride was evaporated. The residue was instantly dissolved in dry THF and refridgerated until used. No purity analysis or weighing were performed.

Workup

  1. temperatureheated
  2. temperatureto reflux for 1 h
  3. temperatureThe reaction was cooled
  4. customthe excess thionyl chloride was evaporated
  5. dissolutionThe residue was instantly dissolved in dry THF

Sources & evidence

ORD record
ord-afde1f8bf6b04f7ba3c55d8402b2f1ee
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

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