反应详情

1-(3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)guanidine (85 mg, 0.35 mmol), 3-(2-(3-methoxyphenyl)acetyl)dihydro-2H-pyran-4(3H)-one (86 mg, 0.35 mmol) and potassium carbonate (47.9 mg, 0.35 mmol) in ethanol (2 mL) were heated to 60° C. over night. DCM and water were added and the organic phase was separated and the solvent was removed under reduced pressure. The crude product was purified by preparative HPLC yielding N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-(3-methoxybenzyl)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-amine (10.00 mg, 6%).

1. customthe organic phase was separated
2. customthe solvent was removed under reduced pressure
3. customThe crude product was purified by preparative HPLC