反应详情

3-(2-(Cyclopentyloxy)acetyl)dihydro-2H-pyran-4(3H)-one (280 mg, 1.24 mmol), 1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)guanidine (1 equiv.) and potassium carbonate (2 equiv.) were heated to 50° C. over night in EtOH (5 mL). The crude product was extracted into DCM, the organic phase collected and solvent evaporated. The crude product was purified by flash chromatography (0-100% EtOAc in Heptane). The purity was not satisfactory so further purification on prepHPLC was performed to afford the title compound (83 mg, 16% yield).

1. extractionThe crude product was extracted into DCM
2. customthe organic phase collected
3. customsolvent evaporated
4. customThe crude product was purified by flash chromatography (0-100% EtOAc in Heptane)
5. customThe purity was not satisfactory so further purification on prepHPLC